Compound could block fat in Type 1 diabetics, Augusta University researchers find
Buildup of a particular kind of fat leads to problems with heart and kidney disease in people with type 1 diabetes.
But researchers at Augusta University have found a novel compound that, in an animal model, blocks the creation of the fats in the digestive system without harming the level of growth hormone, which would be important in these diabetic patients because it is often diagnosed in children.
How the compound does this could also provide a way of looking at a new therapy, one of the co-authors said.
The study, published this month in the Proceedings of the National Academy of Sciences, looked at the receptors for the growth hormone-releasing hormone. They are normally found in the pituitary gland, but in a rat model induced to have what resembles type 1 diabetes, these receptors were also found to be very prevalent in the small intestine.